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Today's reading - Epigenetics of obesity 1/10
Learning/reflections, for anyone interested!
"environmental exposures in critical developmental periods can affect epigenetic marks profile and result in obesity"
#SupportNotStigma #PublicHealth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213306/#:~:text=Epigenetic%20marks%2C%20or%20%E2%80%9Cimprinting%E2%80%9D,associated%20with%20susceptibility%20to%20obesity.
Learning/reflections, for anyone interested!
"environmental exposures in critical developmental periods can affect epigenetic marks profile and result in obesity"
#SupportNotStigma #PublicHealth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213306/#:~:text=Epigenetic%20marks%2C%20or%20%E2%80%9Cimprinting%E2%80%9D,associated%20with%20susceptibility%20to%20obesity.
For a more visual understanding of obesity epigenetics, this is useful. 2/10
Here is what we know:
- BMI
heritable (40% - 70%) risk of weight
(your predisposition)
Our environment has changed++;
complex food environment 
need for activity
Here is what we know:
- BMI
heritable (40% - 70%) risk of weight (your predisposition)
Our environment has changed++;
complex food environment need for activity
But, NOT everyone weight if they have pre-disposition 3/10
- Pre-disposition is impacted by our epigenome, which is impacted by our environment
- Epigenome modulates interaction between our genes and environment
- This interaction = your phenotype (lean, overweight, obesity)
weight if they have pre-disposition 3/10- Pre-disposition is impacted by our epigenome, which is impacted by our environment
- Epigenome modulates interaction between our genes and environment
- This interaction = your phenotype (lean, overweight, obesity)
Epigenetics = interface between our genome and the environment. 4/10
What happens EARLY in life is important++
e.g. differential nutrient exposure in pregnancy can alter risks of metabolic disorders (including obesity, T2DM)
Epigenetic changes = can turn a gene off or on
What happens EARLY in life is important++
e.g. differential nutrient exposure in pregnancy can alter risks of metabolic disorders (including obesity, T2DM)
Epigenetic changes = can turn a gene off or on
How do epigenetic changes happen? 5/10
One example:
- Maternal nutrition impacts risk in adult offspring AND in 2nd generation
- But not just about weight e.g. where pregnant women were starved/poor nutrition risk of metabolic disease in offspring also
One example:
- Maternal nutrition impacts risk in adult offspring AND in 2nd generation
- But not just about weight e.g. where pregnant women were starved/poor nutrition
risk of metabolic disease in offspring also
The epigenome of visceral fat (with the abdominal cavity and associated organs) is different between lean versus non-lean people. 6/10
New research - can metabolic disorders be switched off?
We inherit gene sequences from both parents, but NOT ALL become imprinted.
New research - can metabolic disorders be switched off?
We inherit gene sequences from both parents, but NOT ALL become imprinted.
Epigenetic switch? 7/10
https://www.sciencedaily.com/releases/2016/01/160128133352.htm
What does this point us towards?
- Possible epigenetic therapies for metabolic diseases in the future
- Better support for families during early years development!!
https://www.sciencedaily.com/releases/2016/01/160128133352.htm
What does this point us towards?
- Possible epigenetic therapies for metabolic diseases in the future
- Better support for families during early years development!!
Much new research being done in this area 8/10
Example:
Polygenic Prediction of Weight and Obesity
Trajectories from Birth to Adulthood https://www.cell.com/cell/pdf/S0092-8674(19)30290-9.pdf
Example:
Polygenic Prediction of Weight and Obesity
Trajectories from Birth to Adulthood https://www.cell.com/cell/pdf/S0092-8674(19)30290-9.pdf
Reflections: 9/10
Current environment 'encourages' variations inweight
We still promote idea of a 'normal BMI' without being aware of epigenome influence on weight
Might beweight stigma if we adopt idea of a 'best weight'
And, we still need more early years support!
Current environment 'encourages' variations in
weightWe still promote idea of a 'normal BMI' without being aware of epigenome influence on weight
Might be
weight stigma if we adopt idea of a 'best weight' And, we still need more early years support!
Reflections: 10/10
How much metabolic disorder could be due to weight cycling, fad diets, internalised stigma, weight-related bullying due to fighting a naturally higher weight in today's society?
Could this change how we talk about weight?
#SupportNotStigma #PublicHealth
How much metabolic disorder could be due to weight cycling, fad diets, internalised stigma, weight-related bullying due to fighting a naturally higher weight in today's society?
Could this change how we talk about weight?
#SupportNotStigma #PublicHealth
