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So, which doctors should you believe about the effectiveness of hydroxychloroquine?
The ones whose views derive from RCTs.
It really is as simple as that.
And what do RCTs tell us?
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The ones whose views derive from RCTs.
It really is as simple as that.
And what do RCTs tell us?
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After exposure to SARS-CoV-2, hydroxychloroquine doesn't significantly lower the risk of infection https://www.nejm.org/doi/full/10.1056/NEJMoa2016638
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Among outpatients with early COVID-19, hydroxychloroquine doesn't significantly reduce symptoms https://www.acpjournals.org/doi/10.7326/M20-4207
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In hospitalized patents with mild to moderate COVID-19, hydroxychloroquine (three weeks of it!) doesn't help clear the virus https://www.bmj.com/content/369/bmj.m1849
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In hospitalized patients with mild-moderate COVID-19, hydroxychloroquine doesn't improve symptoms, whether or not it's combined with azithromycin https://www.nejm.org/doi/full/10.1056/NEJMoa2019014
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There are other RCTs, and @methodsmanmd has summarized them all here. No doubt we'll see more in the months ahead. https://twitter.com/methodsmanmd/status/1291072016121049091?s=20
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To sum up:
- Only RCTs can tell us if a drug works or not.
- The RCTs of hydroxychloroquine are overwhelmingly negative.
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- Only RCTs can tell us if a drug works or not.
- The RCTs of hydroxychloroquine are overwhelmingly negative.
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Having said that, I'll add this:
Hydroxychloroquine is nowhere near as dangerous as some have suggested. It's actually a pretty safe drug.
But that is a thread for another day.
/ end (for now)
Hydroxychloroquine is nowhere near as dangerous as some have suggested. It's actually a pretty safe drug.
But that is a thread for another day.
/ end (for now)
Here's the podcast. The sooner we stop talking about hydroxychloroquine for COVID-19, the better. https://twitter.com/JAMA_current/status/1294296970140549122?s=20
