Read on Twitter
A thread on "long covid", which describes long-term symptoms of Covid-19.
My point here is that infections matter, not just deaths.
My point here is that infections matter, not just deaths.
An in-depth interview with someone suffering long-covid symptoms.
This group of people are often called "long haulers", and they don't seem to be very rare.
This group of people are often called "long haulers", and they don't seem to be very rare.
Self-reported long hauler symptoms.
https://static1.squarespace.com/static/5e8b5f63562c031c16e36a93/t/5f20f07af57a1f3b8b3d5045/1595994237318/2020+Survivor+Corps+COVID-19+%27Long+Hauler%27+Symptoms+Survey+Report+%28revised+July+25%29.pdf
https://static1.squarespace.com/static/5e8b5f63562c031c16e36a93/t/5f20f07af57a1f3b8b3d5045/1595994237318/2020+Survivor+Corps+COVID-19+%27Long+Hauler%27+Symptoms+Survey+Report+%28revised+July+25%29.pdf
"From ‘brain fog’ to heart damage, COVID-19’s lingering problems alarm scientists"
https://www.sciencemag.org/news/2020/07/brain-fog-heart-damage-covid-19-s-lingering-problems-alarm-scientists?fbclid=IwAR01S32yQgHdIkAI9dF3ikcZ5KhQi_kOojCFodWkvoKphkrygOMRCA5cKQo
https://www.sciencemag.org/news/2020/07/brain-fog-heart-damage-covid-19-s-lingering-problems-alarm-scientists?fbclid=IwAR01S32yQgHdIkAI9dF3ikcZ5KhQi_kOojCFodWkvoKphkrygOMRCA5cKQo
A big question is about how rare these long haulers are. The data aren't clear on this, but we know it isn't incredibly rare. https://www.telegraph.co.uk/politics/2020/08/05/mps-hear-aftereffects-coronavirus-can-linger-months-cause-lasting/
Now a study of 60 COVID-19 patients published in Lancet this week finds that 55% of them were still displaying such neurological symptoms during follow-up visits three months later. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30228-5/fulltext
The data seems to be slowly trickling out, but it honestly doesn’t look promising. https://doi.org/10.1136/bmj.m2815
"To summarise, persistent respiratory complications following covid-19 may cause substantial population morbidity, and optimal management remains unclear." https://www.bmj.com/content/370/bmj.m3001
Looks like a potentially great resource for long haulers.
"When I found out about this website, the Post-COVID Hub, I can’t tell you how huge it was. It was like someone was finally acknowledging what is happening." https://www.post-covid.org.uk/get-support/
"When I found out about this website, the Post-COVID Hub, I can’t tell you how huge it was. It was like someone was finally acknowledging what is happening." https://www.post-covid.org.uk/get-support/
https://twitter.com/drericding/status/1293113322678747137?s=21 https://twitter.com/DrEricDing/status/1293113322678747137
“Around 10% of patients who have tested positive for SARS-CoV-2 virus remain unwell beyond three weeks, and a smaller proportion for months.”
https://twitter.com/trishgreenhalgh/status/1293148324107821058?s=21 https://twitter.com/trishgreenhalgh/status/1293148324107821058
https://twitter.com/trishgreenhalgh/status/1293148324107821058?s=21 https://twitter.com/trishgreenhalgh/status/1293148324107821058
Long covid in primary care: assessment and initial management of patients with continuing symptoms
On the psychiatric effects of Covid:
"55% of the sample presented a clinical score for at least one mental disorder."
"Females suffered more than males, scoring higher in all the measures."
"COVID-19... is associated with psychiatric implication." https://www.sciencedirect.com/science/article/pii/S0889159120316068#b0015
"55% of the sample presented a clinical score for at least one mental disorder."
"Females suffered more than males, scoring higher in all the measures."
"COVID-19... is associated with psychiatric implication." https://www.sciencedirect.com/science/article/pii/S0889159120316068#b0015
A summary of a few recent papers on the neurological/psychological issues resulting from Covid.
Articles coming in the following tweets.
Articles coming in the following tweets.
For severely ill patients (post-hospitalization):
The survey showed that more than half of the 402 patients monitored after being treated for the virus experienced at least one of these disorders: PTSD, anxiety, insomnia and depression. https://uk.reuters.com/article/us-health-coronavirus-disorders/some-covid-19-survivors-suffer-psychiatric-disorders-italian-study-says-idUKKCN24Z21O
The survey showed that more than half of the 402 patients monitored after being treated for the virus experienced at least one of these disorders: PTSD, anxiety, insomnia and depression. https://uk.reuters.com/article/us-health-coronavirus-disorders/some-covid-19-survivors-suffer-psychiatric-disorders-italian-study-says-idUKKCN24Z21O
On previously hospitalized patients:
"At 8-12 weeks post admission, 134 patients were available for follow up and 110 attended. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue)
with reduced HRQoL. "
https://www.medrxiv.org/content/medrxiv/early/2020/08/14/2020.08.12.20173526.full.pdf
"At 8-12 weeks post admission, 134 patients were available for follow up and 110 attended. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue)
with reduced HRQoL. "
https://www.medrxiv.org/content/medrxiv/early/2020/08/14/2020.08.12.20173526.full.pdf
German study of 100 patients (67 recovered at home, while 33 required hospitalization):
"CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%)..." https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916
"CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%)..." https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916
US, n=270 (nonhospitalized):
"35% had not returned to their usual state of health when interviewed 2–3 weeks after testing. Among persons aged 18–34 years with no chronic medical conditions, one in five had not returned to their usual state of health."
https://www.cdc.gov/mmwr/volumes/69/wr/mm6930e1.htm?s_cid=mm6930e1_w
"35% had not returned to their usual state of health when interviewed 2–3 weeks after testing. Among persons aged 18–34 years with no chronic medical conditions, one in five had not returned to their usual state of health."
https://www.cdc.gov/mmwr/volumes/69/wr/mm6930e1.htm?s_cid=mm6930e1_w
@BretWeinstein and @HeatherEHeying chat about potential dangers of "mild" cases which could end up showing long-term effects (including reduced life expectancy)
https://twitter.com/bmj_latest/status/1303216999837954048?s=21 https://twitter.com/bmj_latest/status/1303216999837954048
An old paper has been updated.
"COVID-19 causes cardiac dysfunction in up to 50% of patients, but the pathogenesis remains unclear."
->
"Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear."
New: https://www.biorxiv.org/content/10.1101/2020.08.25.265561v2
"COVID-19 causes cardiac dysfunction in up to 50% of patients, but the pathogenesis remains unclear."
->
"Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear."
New: https://www.biorxiv.org/content/10.1101/2020.08.25.265561v2
A great resource for keeping track of the medical literature https://www.uptodate.com/home/covid-19-access
Great article about the knowns and unknowns of long-term damage from Covid:
https://www.nature.com/articles/d41586-020-02598-6
https://www.nature.com/articles/d41586-020-02598-6
I think this is really well said:
https://twitter.com/ascotblack/status/1305212513517293568?s=21 https://twitter.com/AscotBlack/status/1305212513517293568
https://twitter.com/ascotblack/status/1305212513517293568?s=21 https://twitter.com/AscotBlack/status/1305212513517293568
@edyong209's article on what we know and what we don't know about heart issues.
Lots of good sources (many already in this thread), and a fairly nuanced discussion, which is refreshing. https://www.theatlantic.com/health/archive/2020/09/covid-19-heart-pandemic-coronavirus-myocarditis/616420/
Lots of good sources (many already in this thread), and a fairly nuanced discussion, which is refreshing. https://www.theatlantic.com/health/archive/2020/09/covid-19-heart-pandemic-coronavirus-myocarditis/616420/
"This document is a brief summary of published evidence about the sequelae of COVID-19 and ongoing studies of its long-term health effects. Included are manuscripts published in peer-reviewed journals or on pre-print servers through August 31, 2020. " https://globalhealth.washington.edu/news/2020/09/04/summary-covid-19-long-term-health-effects-emerging-evidence-and-ongoing
"A dynamic review of the evidence around ongoing Covid19 symptoms (often called Long Covid)."
People are looking for perfect studies on long covid, and tend to denounce anything short of that. It simply isn't a reasonable ask at this point in time.
https://evidence.nihr.ac.uk/themedreview/living-with-covid19/
People are looking for perfect studies on long covid, and tend to denounce anything short of that. It simply isn't a reasonable ask at this point in time.
https://evidence.nihr.ac.uk/themedreview/living-with-covid19/
Long Covid update:
"We analysed data from 4182 incident cases of COVID-19 who logged their symptoms prospectively in the COVID Symptom Study app. 558 (13.3%) had symptoms lasting >28 days, 189 (4.5%) for >8 weeks and 95 (2.3%) for >12 weeks." https://www.medrxiv.org/content/10.1101/2020.10.19.20214494v1
"We analysed data from 4182 incident cases of COVID-19 who logged their symptoms prospectively in the COVID Symptom Study app. 558 (13.3%) had symptoms lasting >28 days, 189 (4.5%) for >8 weeks and 95 (2.3%) for >12 weeks." https://www.medrxiv.org/content/10.1101/2020.10.19.20214494v1
