So Susan Rice is apparently leading the race to be Biden's running mate. Not great news for Israel, definitely not for Netanyahu. She was a big proponent of the Iran Deal, and in many ways unfriendly. https://twitter.com/peterbakernyt/status/1288083600160808962
From @DrMichaelOren’s book “Ally”
Democrats, and quite a few Israelis, including Oren, didn't like Netanyahu speaking in Congress over Obama's opposition, but Rice saw it as a racist move: “In her view, the Israeli leader did everything but ‘use the N-word in describing the president.’ ” https://www.nytimes.com/2015/10/09/world/middleeast/ex-adviser-to-obama-says-susan-rice-accused-israeli-leader-of-racism.html
I imagine all of Biden's running mates are at some level in favor of the Iran Deal and would have opposed Netanyahu speaking in Congress. What's unique is that there's a history here, and it's tense.