@deoxyexplorer on periop oxygenation. ‘I don’t know the answers for any of those questions’ spoiler alert! #EBPOMLondon2020

Speaking for myself only, I am very conscious of FiO2 during surgery- what about you @GongGasGirl @djsPerth @jcwright99 @meganliseallen @Pranola1 @DoctorBelP1

Hypoxaemia is still a problem under anaesthesia especially during induction/emergence. 6.8% of patients. @Atul_Gawande #EBPOMLondon2020

No titration of oxygen that patients were receiving in a UK study to normoxaemia. #EBPOMLondon2020

What is the problem with hyperoxaemia? Maybe it prevents wound infections- after all hyperbaric oxygen is good. @OutcomesRC #EBPOMLondon2020

Advocate 80% O2: bad for bacteria.
Pulmonary complications? Breathing 100% atelectasis. Oxidative stress may be the mechanism- over time leads to fibrosis. #EBPOMLondon2020

PROXI trial- no diff in SSi 30% vs 80%.
Lower short term mortality in 80% but ?increase 30dm https://academic.oup.com/bja/article/119/1/140/3897059 @EBPOM #EBPOMLondon2020

Common themes: identifying right patients and right time to receive supplemental O2 likely to be more beneficial than high FiO2 for all intraop. #EBPOMLondon2020 @deoxyexplorer

@mike_grocott ‘no mechanistic plausibility for low FiO2’ but concerns about lung injury from too high FiO2, but still insufficient evidence to justify any particular FiO2.