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We are pleased to be a very small part of an international COVID-19 consortium assembled by Nevan Krogan here at UCSF. The latest paper from the group just appeared online. [1/3] @grosse_lab https://www.cell.com/cell/fulltext/S0092-8674(20)30811-4
...and while the phosopho-proteome is cool, the most interesting part for us came from images obtained by @grosse_lab showing that SARS-CoV2 induces formation of crazy, branched filopodia. [2/3]
![...and while the phosopho-proteome is cool, the most interesting part for us came from images obtained by @grosse_lab showing that SARS-CoV2 induces formation of crazy, branched filopodia. [2/3]](https://pbs.twimg.com/media/EboRLiVUwAAdX5b.jpg "...and while the phosopho-proteome is cool, the most interesting part for us came from images obtained by @grosse_lab showing that SARS-CoV2 induces formation of crazy, branched filopodia. [2/3]")
...while EM's from the NIH/NIAID/Rocky Mountain Laboratories in Montana (which has electron microscopes in a BSL4 facility) show that the viruses bud primarily off of these filopodia. [3/3] @grosse_lab
![...while EM's from the NIH/NIAID/Rocky Mountain Laboratories in Montana (which has electron microscopes in a BSL4 facility) show that the viruses bud primarily off of these filopodia. [3/3] @grosse_lab](https://pbs.twimg.com/media/EboRxsdU8AI1SpO.jpg "...while EM's from the NIH/NIAID/Rocky Mountain Laboratories in Montana (which has electron microscopes in a BSL4 facility) show that the viruses bud primarily off of these filopodia. [3/3] @grosse_lab")
The way the virus particles are scattered along the filopodia (rather than sitting at the tip) looks a bit like what the Marburg virus does, and makes me wonder whether Myosin X is involved. Calling @_OmQu [4/3] https://pubmed.ncbi.nlm.nih.gov/23940347/
