Is there such a thing as PRIMARY PULMONARY MELANOMA?? What if melanoma presents exclusively in the lung? No evidence of skin, mucosal or ocular primary? Not even after exhaustive evaluation? AND lung melanoma is a solitary 10 cm mass? Did I pique your interest? See 👇1/
Delighted to share latest study from our group that sorts out what these puzzling tumors represent. Using NGS, we found that despite no evidence of primary, lung-only melanomas consistently show a UV signature. @ModernPathology https://rdcu.be/b49nB 
https://www.nature.com/articles/s41379-020-0594-0 2/
Lung-only melanoma: UV mutational signature supports origin from occul

Lung-only melanoma: UV mutational signature supports origin from occult cutaneous primaries and argues against the concept of primary pulmonary melanoma

https://rdcu.be/b49nB
This is direct evidence that lung-only melanomas are metastases from occult (likely regressed) cutaneous melanomas... as lung is, of course, one of the places “where the sun don’t shine”. 3/
This is direct evidence that lung-only melanomas are metastases from occult (likely regressed) cutaneous melanomas... as lung is, of course, one of the places “where the sun don’t shine”. 3/
This is direct evidence that lung-only melanomas are metastases from occult (likely regressed) cutaneous melanomas... as lung is, of course, one of the places “where the sun don’t shine”. 3/
The concept of primary pulmonary melanoma has been in the literature (and WHO) for years but has remained controversial because 1) no native melanocytes in the lung, 2) skin melanomas known to regress, 3) mets to lung extremely common & can be solitary. 4/
So always really neat so be able to use new technology to clarity some age-old dilemmas and “entities”. 5/
Super-important message for pathologists: solitary (even if very large) masses in the lung with no known primary ≠ lung carcinoma. Among other possibilities, DDx includes metastatic melanoma. These can be VERY epithelioid & can even stain for keratins đŸ˜±. So watch out! 6/
Was a great pleasure to work on this with our incredibly talented fellow Chen Yang. Great job @ycharzy! And thanks to all collaborators – was great to branch out to work w/ our phenomenal melanoma team @alexshoushtari @fsanchezvega Klaus Busam. Thanks for great collaboration! 7/
And thanks @MLadanyi and our entire molecular team @MSKPathology for the incredible resource that our NGS platform represents for patient care and research. The end 8/
Please also see this post by @ycharzy with a case example and more on this study https://twitter.com/ycharzy/status/1275976807741820928?s=20
You can follow @natasharekhtman.
Tip: mention @twtextapp on a Twitter thread with the keyword “unroll” to get a link to it.

Latest Threads Unrolled:
Those who think consciousness raising & movement building are disconnected, or even a distraction from electoral politics have not paid attention to the history of social change.In this thread, we
Read more
The 2020s will be known as the Remote Work decadeA few predictions of what is likely to emerge[ a thread ] Third Space: Office and Working from Home will
Read more
1/29: Have you ever had a concept explained to you that helps frame complex issues you’ve been wrestling with and opens your eyes to new possibilities? A concept that I
Read more
By continuing to use the site, you are consenting to the use of cookies as explained in our Cookie Policy to improve your experience.