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Ready to explore the intrinsic world of neurons during the evolution of memories?
Check out my newly published review from the Cai lab ( @denisejcai) on neuronal intrinsic excitability and memory!
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Free access link: https://authors.elsevier.com/c/1bGTq3qNaA4OWo
Check out my newly published review from the Cai lab ( @denisejcai) on neuronal intrinsic excitability and memory!
Thread
Free access link: https://authors.elsevier.com/c/1bGTq3qNaA4OWo
Maintaining an active social network is for sure important for us to navigate the world.
Equally if not more important, each individual’s unique personality also significantly affects how we interpret the world around us and relate to others.
A neuron’s tendency to fire action potentials, or its intrinsic excitability, plays a critical role in this balancing act between single cells and their function as part of neuronal ensembles, and between the stability and flexibility of memories.
First, intrinsic excitability regulates memory allocation. Neurons with higher excitability are more likely to be recruited into a neuronal ensemble during memory encoding compared to their less excitable neighbors.
Second, a transient increase in excitability after learning may work synergistically with mechanisms that influence synaptic plasticity to promote the consolidation of memories.
Finally, intrinsic excitability is also involved in the dynamic updating of memories, opening a window of time for both strengthening and integrating new information into existing memories.
Thanks to all the co-authors: @not_kristie @MauseWhisperer @mysteriousjoe_ #PhilDong @SimaRabinowitz @melcregor @tristanshuman @denisejcai.
Excited to read more? Please check out our review!
Free access: https://authors.elsevier.com/c/1bGTq3qNaA4OWo
Excited to read more? Please check out our review!
Free access: https://authors.elsevier.com/c/1bGTq3qNaA4OWo
