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Antivirals approved other viruses being tested against SARS-CoV-2 in randomized controlled trials (RCT). Such drug repurposing â testing drugs approved for other viruses â is the logical shortcut for drug development & approval process which usually lasts ~10 years. (1/n)
Most antivirals fail preclinical testing. At first, studies performed on cells in culture. If successful, the antiviral is tested in animals. Then comes the most time consuming part i.e. clinical trials. (2/n)
Then if the laws of economics permit, the antiviral enters clinical trial phase which in itself comprises 4 phases.
Phase I: safety & dosing
Phase II: efficacy & safety in a small no. of patients
Phase III: in large groups of people. If the antiviral is... (3/n)
Phase I: safety & dosing
Phase II: efficacy & safety in a small no. of patients
Phase III: in large groups of people. If the antiviral is... (3/n)
sufficiently efficacious & safe. The trials stop here and the drug goes for approval by the FDA.
Phase IV: Post approval surveillance.
Since already approved drugs have undergone all this, the process gets sped up. But it still takes a lot of time. (4/n)
Phase IV: Post approval surveillance.
Since already approved drugs have undergone all this, the process gets sped up. But it still takes a lot of time. (4/n)
I am putting it out here because Ramdev has pulled coronil outta somewhere the sun doesn't shine and claimed that it has undergone RCT. You be the judge. (5/5)
Typos*
Copula and preposition drops*
Copula and preposition drops*
