Read on Twitter
"They all developed anti-SARS-CoV-2 antibodies and a significant T cell response detectable up to 69 days after symptom onset... Six out of eight contacts developed a SARS-CoV-2-specific T cell response against structural and/or accessory proteins that lasts up to 80 days post" https://twitter.com/BallouxFrancois/status/1275346757342371840
To add to:
- SARS-CoV-2-specific T cells exhibit unique features characterized: https://www.biorxiv.org/content/10.1101/2020.06.08.138826v1.abstract
- Intrafamilial Exposure Induces Cellular Immune Response without Seroconversion: https://www.medrxiv.org/content/10.1101/2020.06.21.20132449v1 https://twitter.com/BallouxFrancois/status/1277566739111436288
- SARS-CoV-2-specific T cells exhibit unique features characterized: https://www.biorxiv.org/content/10.1101/2020.06.08.138826v1.abstract
- Intrafamilial Exposure Induces Cellular Immune Response without Seroconversion: https://www.medrxiv.org/content/10.1101/2020.06.21.20132449v1 https://twitter.com/BallouxFrancois/status/1277566739111436288
But take into account: https://twitter.com/Seempleetoo/status/1280488875316609025
"In...the H1N1 influenza pandemic, pre-existing T cell immunity existed in the adult population, which focused on the more conserved internal influenza viral proteins. The presence of cross-reactive T cells was found to correlate with less severe disease."
https://www.cell.com/cell/pdf/S0092-8674(20)30610-3.pdf
https://www.cell.com/cell/pdf/S0092-8674(20)30610-3.pdf
"- Humoral immune responses decrease with age. This is illustrated by an approximately 50% reduction in influenza vaccine efficacy in elderly individuals.
- In general, virus-specific antibody titers are lower in elderly adults compared with young adults."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822389/pdf/nihms171795.pdf
- In general, virus-specific antibody titers are lower in elderly adults compared with young adults."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822389/pdf/nihms171795.pdf
"Together with currently introduced, novel serology tests, the data generated by such studies may critically inform evidence-based risk evaluation, patient monitoring, adaptation of containment methods, and last but not least, vaccine development." https://www.medrxiv.org/content/10.1101/2020.04.17.20061440v1
"In a study by Grifoni et al. ( https://www.cell.com/cell/pdf/S0092-8674(20)30610-3.pdf), reactivity was detected in 50% of donor blood samples obtained in the USA between 2015 and 2018, before SARS-CoV-2 appeared in the human population." https://www.nature.com/articles/s41577-020-0389-z
Within 2 days:
@BallouxFrancois: "There have been several studies investigating the proportion of asymptomatic infection for seasonal flu (influenza A). The proportion ranges between ~50-75%, not that different than for SARSCoV2"
& @nanogenomic (thread): https://twitter.com/nanogenomic/status/1282573046532849664
@BallouxFrancois: "There have been several studies investigating the proportion of asymptomatic infection for seasonal flu (influenza A). The proportion ranges between ~50-75%, not that different than for SARSCoV2"
& @nanogenomic (thread): https://twitter.com/nanogenomic/status/1282573046532849664
"although patients who recovered displayed multiple hallmarks of effective immune recognition, the wide spectrum of neutralizing activity observed suggests that vaccines might require strategies to selectively target the most potent neutralizing epitopes" https://twitter.com/EricTopol/status/1282653698498260992
See entire threads with additional elements / points of view about T cells and their potential role: https://twitter.com/abledoc/status/1283235974261047297
"Yes. This is definitely another issue. Even with multiplex you can miss very low titer response. Or a T cell only response." From @VincentRK
See thread with multiple conversations https://twitter.com/VincentRK/status/1284340106938155009?s=19
See thread with multiple conversations https://twitter.com/VincentRK/status/1284340106938155009?s=19
"Prof Adrian Hayday @HaydayLab summarizes interesting immunological signatures from a deep immunophenotyping of 100 #COVID19 patients & controls": https://twitter.com/nanogenomic/status/1285124382948331520?s=19
"then, there is a third set of B-cells. They are called memory B-cells. They actually don't make antibody. But they get quickly reactivated and become plasmablasts if you get reinfected."
See full thread - must read https://twitter.com/florian_krammer/status/1285618977654407169?s=19
See full thread - must read https://twitter.com/florian_krammer/status/1285618977654407169?s=19
Again, an excellent thread from @nanogenomic providing an opportunity to catch up, with different prisms when analysing potential immunity in the context of #covid19 / #SARSCoV2 https://twitter.com/nanogenomic/status/1286004452474814464?s=19
