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1/ As unbelievable as it sounds, it appears the RECOVERY trial confused hydroxy*chloroquine* (HCQ) w/ the drug class hydroxy*quinolines*
The investigators of RECOVERY said they based HCQ dosing off treatment of amoebic dysentery, which is why they decided 2,400mg of HCQ on day 1
The investigators of RECOVERY said they based HCQ dosing off treatment of amoebic dysentery, which is why they decided 2,400mg of HCQ on day 1
2/ HCQ isn't used for amoebic dysentery though
Iodoquinol (a hydroxyquinoline) is used for amoebic dysentery at ~2,000 mg daily. (Oral absorption is low, so high doses are tolerable)
HCQ, however, is readily absorbed orally and a dose this high approaches lethal dose of 4,000mg
Iodoquinol (a hydroxyquinoline) is used for amoebic dysentery at ~2,000 mg daily. (Oral absorption is low, so high doses are tolerable)
HCQ, however, is readily absorbed orally and a dose this high approaches lethal dose of 4,000mg
3/ Hydroxy*quinoline* in treatment of COVID-19 has been confused with hydroxy*chloroquine* before by UK researchers, even in prestigious journals such as the BMJ. https://twitter.com/__ice9/status/1272237961040494593?s=20
4/ In my 8 years of medical school/residency training, I've never heard of a patient given 2,400mg per day of HCQ.
Furthermore, the lethal dose of HCQ is far lower than the "6 or 10 times" 2,400mg as stated by RECOVERY chief investigator Martin Landray (lethal dose ~4,000mg).
Furthermore, the lethal dose of HCQ is far lower than the "6 or 10 times" 2,400mg as stated by RECOVERY chief investigator Martin Landray (lethal dose ~4,000mg).
5/ In summary, it appears the RECOVERY trial based its HCQ dosage off a different drug class w/ a VERY different absorption profile...giving patients a near lethal dose of HCQ.
Here is @xazalbert's interview with Martin Landray in @france_soir. http://www.francesoir.fr/politique-monde/interview-exclusive-martin-landray-recovery-hydroxychloroquine-game-over-uk
Here is @xazalbert's interview with Martin Landray in @france_soir. http://www.francesoir.fr/politique-monde/interview-exclusive-martin-landray-recovery-hydroxychloroquine-game-over-uk
6/ Again this type of drug confusion is almost unbelievable to me, but I've yet to hear a rebuttal from RECOVERY investigators justifying this high dose.
Researchers exposing this negligence are @__ice9, @richardursomd, @EdmundFordham, @jpkiekens and, of course, @france_soir.
Researchers exposing this negligence are @__ice9, @richardursomd, @EdmundFordham, @jpkiekens and, of course, @france_soir.
