Read on Twitter
Our (co-inventors @McLellan_Lab) COVID-19 vaccine (spike delivered by @moderna_tx's mRNA) was just injected into the 1st human in phase 1 trial, only 66 days after viral sequence release... a testament to rapid vaccine development for emerging diseases
https://www.niaid.nih.gov/news-events/nih-clinical-trial-investigational-vaccine-covid-19-begins
https://www.niaid.nih.gov/news-events/nih-clinical-trial-investigational-vaccine-covid-19-begins
A second phase 1 clinical site has been added for our ( @NIAIDNews @McLellan_Lab @moderna_tx) COVID-19 vaccine. Welcome to the party, @emoryhealthcare http://www.niaid.nih.gov/news-events/atlanta-site-added-nih-clinical-trial-vaccine-covid-19 – bei NIH Vaccine Research Center
http://www.niaid.nih.gov/news-events/atlanta-site-added-nih-clinical-trial-vaccine-covid-19 – bei NIH Vaccine Research Center
"(BARDA) will also support 
@moderna_tx to get Phase 2 and 3 clinical trials of its COVID-19 vaccine (...) developed in partnership with the NIAID." (It's us, ya'll...)
(...oh & @JNJNews nem.) https://www.the-scientist.com/news-opinion/us-selects-two-covid-19-vaccine-candidates-for-huge-investments--67367#.XofSB0XHpKs.twitter
@moderna_tx to get Phase 2 and 3 clinical trials of its COVID-19 vaccine (...) developed in partnership with the NIAID." (It's us, ya'll...) (...oh & @JNJNews nem.)
https://www.the-scientist.com/news-opinion/us-selects-two-covid-19-vaccine-candidates-for-huge-investments--67367#.XofSB0XHpKs.twitter
Look
More phase 1 trial news:
"Moderna's COVID-19 vaccine trial starts enrolling high-dose arm"
Pretty smooth how we announce the high-dose arm of the phase 1 is enrolling & Moderna sprinkles a data teaser...
https://www.fiercebiotech.com/biotech/moderna-s-covid-19-vaccine-trial-starts-enrolling-high-dose-arm
...from their Zika vaccine candidate.
More phase 1 trial news:"Moderna's COVID-19 vaccine trial starts enrolling high-dose arm"
Pretty smooth how we announce the high-dose arm of the phase 1 is enrolling & Moderna sprinkles a data teaser...
https://www.fiercebiotech.com/biotech/moderna-s-covid-19-vaccine-trial-starts-enrolling-high-dose-arm
...from their Zika vaccine candidate.
Bags 
Secured >>> Moderna Announces Award from U.S. Government Agency BARDA for up to $483 Million to Accelerate Development of mRNA Vaccine (mRNA-1273) Against Novel Coronavirus https://www.businesswire.com/news/home/20200416005985/en/Moderna-Announces-Award-U.S.-Government-Agency-BARDA
Secured >>> Moderna Announces Award from U.S. Government Agency BARDA for up to $483 Million to Accelerate Development of mRNA Vaccine (mRNA-1273) Against Novel Coronavirus https://www.businesswire.com/news/home/20200416005985/en/Moderna-Announces-Award-U.S.-Government-Agency-BARDA
Happy Monday Tweetologists....Here is a little of our vaccine clinical trial data teaser for ya.
Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirus
https://bit.ly/3g9Rzi2
*exhales...*
Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirushttps://bit.ly/3g9Rzi2
*exhales...*
Moderna advances late-stage development of its vaccine (mRNA-1273) against COVID-19 https://www.businesswire.com/news/home/20200611005456/en/Moderna-Advances-Late-Stage-Development-Vaccine-mRNA-1273-COVID-19
Our COVID vaccine's (mRNA-1273) immunogenicity in mice is live. As a bonus, we sprinkled in MERS mRNA vaccine efforts that started b4 SARS2 was a thing.
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness (pre-print) https://www.biorxiv.org/content/10.1101/2020.06.11.145920v1
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness (pre-print) https://www.biorxiv.org/content/10.1101/2020.06.11.145920v1
A large collaborative effort, yrs in the making towards prototype pathogen vaccine design & platform delivery between us, @Baric_Lab, @DenisonLab, @McLellan_Lab ... & of course @moderna_tx. (& more) https://twitter.com/KizzyPhD/status/1230390260841971712?s=20
The phase 1 preliminary report is out!!! ENJOY THE READ!!! (and the AMAZING immune responses 
)
"An mRNA Vaccine against SARS-CoV-2 — Preliminary Report" https://www.nejm.org/doi/full/10.1056/NEJMoa2022483
)"An mRNA Vaccine against SARS-CoV-2 — Preliminary Report" https://www.nejm.org/doi/full/10.1056/NEJMoa2022483
Wanna see some new data?
RIGHT NOW: Moderna is presenting our newest data from Phase 1. Tune in https://www.ustream.tv/channel/VWBXKBR8af4
RIGHT NOW: Moderna is presenting our newest data from Phase 1. Tune in
https://www.ustream.tv/channel/VWBXKBR8af4
Safety and Immunogenicity of mRNA-1273 in Older Adults. The paper is out!!! https://www.nejm.org/doi/full/10.1056/NEJMoa2028436?query=featured_home
Moderna Completes Enrollment of Phase 3 COVE Study of mRNA Vaccine Against COVID-19 (mRNA-1273)
Salute to the REAL MVPs (30,000+ people) who gave their time and trust to the science of it all. You are more than data points... You are a heroes!!!
https://apnews.com/press-release/business-wire/business-technology-virus-outbreak-pandemics-public-health-98a3bac421764d46b135691b9a8208d0
Salute to the REAL MVPs (30,000+ people) who gave their time and trust to the science of it all. You are more than data points... You are a heroes!!!
https://apnews.com/press-release/business-wire/business-technology-virus-outbreak-pandemics-public-health-98a3bac421764d46b135691b9a8208d0
94.1%.
100% efficacy against severe COVID for a lil’ razzle dazzle. https://twitter.com/moderna_tx/status/1333381353488994310
100% efficacy against severe COVID for a lil’ razzle dazzle. https://twitter.com/moderna_tx/status/1333381353488994310
And, the age de-escalation begins... https://twitter.com/moderna_tx/status/1337005256132190211
Hopefully, you all will be tuning into the FDA Vaccines and Related Biological Products Advisory Committee Meeting on December 17, 2020 to hear all about the Moderna COVID-19 Vaccine.
In preparation, here is the briefing document full of data: https://www.fda.gov/media/144434/download
In preparation, here is the briefing document full of data: https://www.fda.gov/media/144434/download
The juxtaposition of the EUA announcement in a text with my boss #drbarney with the MERS coronavirus stabilized spike protein bound to antibodies as his phone background is HISTORIC!
“Whoop whoop”!
History reference: https://www.instagram.com/p/CBh_gNZjGkv/?igshid=1opodii0y96k7
“Whoop whoop”!
History reference: https://www.instagram.com/p/CBh_gNZjGkv/?igshid=1opodii0y96k7
mRNA-1273 PEER-REVIEWED PHASE 3 DATA
*anticlimax drumroll* if you read the FDA EUA package...
“94.1% efficacy at preventing Covid-19 illness, including severe disease. Aside from transient local & systemic reactions, no safety concerns were identified” https://www.nejm.org/doi/10.1056/NEJMoa2035389
*anticlimax drumroll* if you read the FDA EUA package...
“94.1% efficacy at preventing Covid-19 illness, including severe disease. Aside from transient local & systemic reactions, no safety concerns were identified” https://www.nejm.org/doi/10.1056/NEJMoa2035389
Good morning esp. to @moderna_tx scientists who woke up a year ago to begin manufacturing clinical-grade mRNA-1273. The beauty of their platform and manufacturing expertise is that it only took 41 days to ship pure "ready-for-muscle" vaccine product. https://www.nature.com/articles/s41586-020-2622-0
https://www.nature.com/articles/s41586-020-2622-0
Most notable about this is that the company "at financial risk" decided to make the product. There wasn't even a confirmed COVID-19 case in the US yet, but PREPAREDNESS.
"Give me six hours to chop down a tree and I will spend the first four sharpening the axe.” x Lincoln
"Give me six hours to chop down a tree and I will spend the first four sharpening the axe.” x Lincoln
Sharpening the axe, we worked together for several years on MERS vaccines. We even knew based on my lab notebooks what doses would work in animals, what exact construct to design, vaccine schedule, etc. etc. It was a data-driven financial risk. Thoughtful.
Today, also marks the anniversary of when we got on the phone with @Baric_Lab to plan challenge experiments. There are 3 mouse strains in that Nature paper b/c we knew @SarahRLeist would make a challenge model in @ least 1 of them, & we wanted to be prepared to challenge asap.
We even knew what the subprotective dose would be (based on MERS work) and used it b/c we also knew the FDA and manuscript reviewers would be concerned about enhancement so we set to prove against the nay-sayers/skeptics. Thoughtful.
... @DenisonLab was also on that call... viral infectivity/neutralization assay development was discussed in detail. We made sure live virus assays could be run, outside of contracting organizations that the whole world would use.... through our friends and colleagues.
... @McLellan_Lab was also on that call... @LabWrapp was going to solve the high definition structure of the spike protein that we were expressing in the vaccine. We needed to know our sequence choice was right. https://science.sciencemag.org/content/367/6483/1260
I should be a collaboration consultant. Booking info in bio hahaha.
Anyways that's what I was doing a year ago.
Anyways that's what I was doing a year ago.
