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Aaron Goodman
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How do neutrophils (PMNs) get from the blood into tissue to kill infection?A TweetorialImmunologyPMNs1. Roll2. Adhere3. Transmigrate through endothelium into tissueThe above process depends on different types of adhesion molecules:1.
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All FDA Antibody Drug Conjugates Heme MaligTweetorial#Goodman_hemeAntibody+Linker+Chemo/toxinMOAFDA approvals (trial)tox (last tweet)Gemtuzumab ozogamicinanti-CD33+calicheamicin (DNA breaker)Frontline AML+7+3 (ALFA,AML15)Pediatric induction
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Cold Blood (short Tweetorial)#Goodman_heme3 confusing diseases1. Cold agglutinin disease 2. Cryoglobulinemia3. Paroxysmal cold hemoglobinuriaTwo of these disease are seen often on both the heme consult service and boards. Cold Agglutinin
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